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Since morphine and oxycodone are extensively metabolized by the liver, avoiding the portal system maximizes the active blood levels you can achieve per dose but minimizes the levels of hepatically created active me- tabolites such as M-6-G.
The analogue to hyperlinks in the scientific literature are citations, that is, the more often an article is cited, the more important it is (Lawrence, Giles & Bollacker, 1999).
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