sex dating in saltburn by the sea yorkshire - Elucidating the role of androgen receptor in breast cancer

Numerous efforts are currently being undertaken to improve prognosis for patients with triple-negative breast cancer.

elucidating the role of androgen receptor in breast cancer-72

The staining was scored separately and the results compared.

The finding that yielded the highest scores was used in the analysis.

Steroid hormone receptors are crucial components of signaling pathways, and act as transcription factors to regulate gene expression.

Androgen receptor is a member of the nuclear receptor superfamily and is known to be involved in a complex network of signaling pathways that collectively regulate cell proliferation.

Our study suggests that loss of androgen receptor in triple-negative breast cancers augurs a worse prognosis, including those with basal-like features.

More work in elucidating its relationship with mechanisms of progression, as well as trials of targeted treatment for androgen receptor-expressing triple-negative tumors, needs to be performed.Correspondence: Dr PH Tan, FRCPA, Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore.E-mail: [email protected] Received ; Revised 20 June 2013; Accepted 21 June 2013Advance online publication 9 August 2013Treatment of triple-negative invasive breast cancers, defined by the absence of estrogen and progesterone receptors and c-erb B2 expression, remains challenging.The study cohort comprised 699 triple-negative breast cancers diagnosed at the Department of Pathology, Singapore General Hospital from 1994 to 2010.Clinicopathological parameters including age, ethnicity, tumor size, tubule formation, nuclear pleomorphism, mitotic score, histologic grade, subtype, associated ductal carcinoma in situ, lymphovascular invasion, axillary lymph node status, tumor borders and growth pattern were reviewed.Recently, it has been suggested that androgen receptor has an emerging role in patients with breast cancer, especially ER-negative tumors.

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